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Phospho PAK4 (Ser474) Antibody

Affinity purified rabbit polyclonal antibody to detect phosphorylation of PAK4 at Ser474 in human, mouse, rat and bovine samples
Catalog #: A1973
$285.00

Product Details

Size 100 µl
Antibody Target Phospho PAK2 (Ser474)
Alternate Name KIAA1142; Serine/threonine-protein kinase PAK 4; p21-activated kinase 4; PAK-4
Host Rabbit
Antibody Type Polyclonal
Isotype IgG
Accession # O96013
Gene ID 10298
Appearance Colorless liquid
Formulation In 0.42% Potassium phosphate; 0.87% NaCl; pH 7.3; 30% glycerol; and 0.01% sodium azide
Purification Affinity purified
Species Reactivity Bovine, Rat, Mouse, Human
Application Immunofluorescence (IF), Western Blotting
Application & Usage WB 1:500 - 1:1000, IF 1:100 - 1:500
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.


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