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Phospho-p53 Antibody

Catalog #: 3515

In stock

$395.00

Product Details

Cat # +Size 3515-100
Size 100 µg
Antibody Target Phospho-p53
Alternate Name TP53 , p53 , LFS1 , TRP53 , P53 , tumor protein p53 , Li-Fraumeni syndrome
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human p53.
Accession # EAW90140
Gene ID 7157
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol; and 0.01% sodium azide.
Purification Affinity purified
Species Reactivity Human, Rat
Application WB 1:500 – 1:1000; IHC 1:100 – 1:200; IF/IC 1:100 – 1:500; IP 1:10 – 1:100. However, the optimal conditions should be determined individually
Positive Control WB: Hela UV-treated; PC12 whole cell lysates; IHC: human breast cancer; IF: PC12 cells
Application & Usage Western blot analysis (0.5-4 µg/ml), immunoprecipitation (5-10 µg/ml), and Immunohistochemistry (20 µg/ml). However, the optimal conditions should be determined individually. The Phospho-p53 (Ser15) antibody detects ~53 kDa Ser15 phosphorylated p53. It do
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. The activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis. p53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro. p53 can apparently be phosphorylated by ATM, ATR, and DNA-PK at Ser15; the phosphorylation impairs the ability of MDM2 to bind p53, promoting both the accumulation and functional activation of p53 in response to DNA damage.


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