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Phospho-Mek1/2 Antibody

based on 1 citations in multiple journalsPhospho-Mek1/2 Antibody14.1 4
Catalog #: 3519
$345.00

Product Details

Cat # +Size 3519-100
Size 100 µl
Antibody Target Phospho-Mek1/2
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide corresponding to amino acids surrounding Ser217/221 of human MEK1/2
Accession # Q02750
Gene ID 400274
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 100 µl purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% sodium azide.
Purification Affinity purified
Species Reactivity Human, mouse, rat
Application Western blot, Immunofluorescence
Application & Usage Western blotting (1:200-1000) and immunocytochemistry (1:100-200). However, the optimal concentrations should be determined individually. The antibody recognizes 45 kDa phospho-Mek1/2 (Ser217/221). It does not detect the unphosphorylated protein.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

MAP kinase kinase 1 (Mek1), also known as mitogen activated protein kinase kinase, MAP kinase kinase, ERK kinase 1 or microtubule-associated protein 2 kinase, is a 43 kDa dual-specificity protein kinase that phosphorylates threonine and tyrosine residues on MAP kinases such as Erk 1 and 2. Mek1 and Mek2 are involved in a diverse array of cellular processes such as stress-activated response, apoptosis, cytokine-induced cell proliferation, and DNA recombination during meiosis. Mek1 and Mek2 are activated by phosphorylation on serine 218 and 222 by serine-threonine kinase, Raf-1, which is part of the p21ras signal transduction pathway.


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Jo, C. et. al. Mitogen-activated Protein Kinase Kinase 1 (MEK1) Stabilizes MyoD through Direct Phosphorylation at Tyrosine 156 During Myogenic Differentiation. J. Biol. Chem., May 2011; 286: 18903 - 18913.
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