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Phospho-MAPKAPK-2 Antibody

Catalog #: 3434
$325.00

Product Details

Cat # +Size 3434-100
Size 100 µg
Antibody Target Phoshpo-MAPKAPK-2
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide corresponding to residues surrounding Thr334 of human MAPKAPK-2
Accession # P49137
Gene ID 9261
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 100 µg (0.5 mg/ml) antigen affinity purified rabbit polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal.
Purification Affinity purified
Species Reactivity Human, mouse
Application Western blot
Application & Usage Western blotting (1 µg/ml). However, the optimal conditions should be determined individually. The antibody detects phosphorylated MAPKAPK-2 (Thr334) of human and mouse origins. Reactivity to other species has not been tested.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

MAP kinase-activated protein kinase-2 (MAPKAPK-2), also known as p45 hsp27 kinase, is a 45-54 kDa serine-threonine protein kinase. MAPKAPK-2 is rapidly phosphorylated and activated in response to stress, cytokines, and chemotactic factors. One of the major substrates of MAPKAPK-2 is hsp27, which stimulates actin polymerization in order to facilitate recovery from destruction of cytoskeleton during cellular stresses. Two isoforms are produced due to alternative splicing of the same gene which differs in their C-terminals. This antibody recognizes both isoforms.


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