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Phospho-IRS (Ser616) Antibody (Clone HIR-B1)

Catalog #: 3105

In stock

$285.00

Product Details

Cat # +Size 3105-100
Size 100 µg
Antibody Target Phospho-IRS
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG1
Immunogen Synthetic peptide phosphorylated at Ser 616 site
Accession # P35568
Gene ID 3667
Appearance Colorless liquid
Concentration 1.0 mg/ml
Formulation 100 µg (1.0 mg/ml) purified mouse monoclonal antibody supplied in PBS with 0.05% (W/V) sodium azide.
Purification Affinity purified
Species Reactivity Human
Application Indirect ELISA, Western blot
Application & Usage The antibody can be used for indirect ELISA and WB.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Insulin receptor substrates (IRS) subtypes are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. The balance between Ser/Thr phosphorylation of IRS has been demonstrated to be an important regulator of insulin signaling. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm’s tumors, and adrenal cortical carcinomas. Does not recognize IRS peptide NOT phosphorylated at Ser616 and will not recognize IRS peptide phosphorylated at Tyr183. Also does not react with riboflavin carrier protein which is known to have multiple phosphate groups.


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