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Phospho-hnRPD (Ser83) Antibody

Polyclonal antibody to detect Phospho-hnRPD (Ser83)
Catalog #: A1731

In stock

$395.00

Product Details

Cat # +Size A1731-100
Size 100 µl
Antibody Target HNRNPD
Alternate Name ARE binding protein AUFI type A; AU-rich element RNA-binding protein 1; AUF; AUF1; AUF1A; Heterogeneous nuclear ribonucleoprotein D0; hnRNP D; hnRNP D0; Hnrnpd; hnRNPD0; HNRPD; HNRPD_HUMAN; P37
Host Rabbit
Antibody Type Polyclonal
Isotype IgG
Accession # Q14103
Gene ID 3184
Concentration 1mg/ml
Formulation In phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol
Purification Affinity purified
Species Reactivity Rat, Mouse, Human
Application Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Western Blotting, ELISA
Application & Usage WB 1:500-1:2000 IHC 1:50-1:200 IF/ICC 1:100-1:500, ELISA (peptide) 1:20000-1:40000
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation.


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