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Phospho-Glucocorticoid Receptor (Ser203) Antibody

Polyclonal antibody to detect endogenous levels of Phospho-Glucocorticoid Receptor (Ser203)
Catalog #: A1728

In stock

$395.00

Product Details

Cat # +Size A1728-100
Size 100 µl
Antibody Target Glucocorticoid receptor
Alternate Name Glucocorticoid receptor, GR, Nuclear receptor subfamily 3 group C member 1, NR3C1, GRL
Host Rabbit
Antibody Type Polyclonal
Isotype IgG
Accession # P04150
Gene ID 2908
Appearance Colorless liquid
Concentration Concentration 1mg/ml
Formulation In phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Purification Affinity purified
Species Reactivity Mouse, Human
Application Immunofluorescence (IF), Immunocytochemistry (ICC), Western Blotting, ELISA
Application & Usage WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA (peptide) 1:20000-1:40000
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth.


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