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Phospho-Cofilin (Ser3) Antibody

Polyclonal antibody to detect endogenous levels of Cofilin (Ser3) in human, mouse and rat samples
Catalog #: A1267
$285.00

Product Details

Cat # +Size A1267-100
Size 100 µl
Antibody Target CFL1
Alternate Name Cofilin-1, 18 kDa phosphoprotein, p18, Cofilin, non-muscle isoform, CFL1, CFL
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthesized peptide derived from human Cofilin around the phosphorylation site of S3
Accession # P23528
Gene ID 3716
Appearance Colorless liquid
Formulation In PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Purification Affinity-chromatography using epitope-specific immunogen
Species Reactivity Human, Mouse, Rat
Application WB, IHC, ELISA
Positive Control WB: COLO205 cell lysate
Application & Usage WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration.


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