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Phospho-Chk2 (Thr68) Antibody

Polyclonal antibody to detect endogenous levels of Chk2 (pThr68) in human, mouse and rat samples
Catalog #: A1265
$285.00

Product Details

Cat # +Size A1265-100
Size 100 µl
Antibody Target CHEK2
Alternate Name Serine/threonine-protein kinase Chk2, CHK2 checkpoint homolog, Cds1 homolog, Hucds1, hCds1, Checkpoint kinase 2, CHEK2
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthesized peptide derived from human Chk2 around the phosphorylation site of T68
Accession # O96017
Gene ID 11200
Appearance Colorless liquid
Formulation In PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Purification Affinity-chromatography using epitope-specific immunogen
Species Reactivity Human, Mouse, Rat
Application WB, IHC, ELISA
Positive Control WB: HeLa cell lysate
Application & Usage WB 1:500-1:2000; ELISA 1:20000; IHC 1:100-1:300
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression.


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