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Phospho-Cdk2 (Thr160) Antibody

Polyclonal antibody to detect endogenous levels of Cdk2 (pT160) in human, mouse and rat samples
Catalog #: A1261
$285.00

Product Details

Cat # +Size A1261-100
Size 100 µl
Antibody Target CDK2
Alternate Name Cyclin-dependent kinase 2, Cell division protein kinase 2, p33 protein kinase, CDK2, CDKN2
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthesized peptide derived from human Cdk2 around the phosphorylation site of T160.
Accession # P24941
Gene ID 1017
Appearance Colorless liquid
Formulation In PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Purification Affinity-chromatography using epitope-specific immunogen
Species Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC
Positive Control WB: HeLa cell lysate
Application & Usage WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus.


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