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Product Details
| Cat # +Size | A1725-100 |
|---|---|
| Size | 100 µl |
| Antibody Target | RAF1 |
| Alternate Name | RAF proto-oncogene serine/threonine-protein kinase, Proto-oncogene c-RAF, cRaf, Raf-1, RAF1, RAF |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | IgG |
| Accession # | P04049 |
| Gene ID | 5894 |
| Appearance | Colorless liquid |
| Concentration | 1mg/ml |
| Formulation | In phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol |
| Purification | Affinity purified |
| Species Reactivity | Rat, Mouse, Human |
| Application | Immunofluorescence (IF), Immunocytochemistry (ICC), Western Blotting, ELISA |
| Application & Usage | WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA (peptide) 1:20000-1:40000 |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity.
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