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Phospho-C-RAF (Ser301) Antibody

Polyclonal antibody to detect endogenous levels of Phospho-C-RAF (Ser301)
Catalog #: A1725
$395.00

Product Details

Cat # +Size A1725-100
Size 100 µl
Antibody Target RAF1
Alternate Name RAF proto-oncogene serine/threonine-protein kinase, Proto-oncogene c-RAF, cRaf, Raf-1, RAF1, RAF
Host Rabbit
Antibody Type Polyclonal
Isotype IgG
Accession # P04049
Gene ID 5894
Appearance Colorless liquid
Concentration 1mg/ml
Formulation In phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol
Purification Affinity purified
Species Reactivity Rat, Mouse, Human
Application Immunofluorescence (IF), Immunocytochemistry (ICC), Western Blotting, ELISA
Application & Usage WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA (peptide) 1:20000-1:40000
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity.


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