Product Details
| Cat # +Size | 3502-100 |
|---|---|
| Size | 100 µg |
| Antibody Target | c-Jun, Phospho |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | Synthetic phospho-peptide corresponding to residues surrounding Ser73 of human cJun |
| Accession # | AAH68522 |
| Gene ID | 3725 |
| Appearance | Colorless liquid |
| Concentration | 0.5 mg/ml |
| Formulation | 100 µg (0.5 mg/ml) affinity-purified rabbit polyclonal phospho-c-Jun (Ser73) antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal. |
| Purification | Affinity purified |
| Species Reactivity | Human, mouse, rat |
| Application | Western blot, Immunohistochemistry |
| Application & Usage | Western blot analysis (1 µg/ml) and Immunohistochemistry (10-20 µg/ml). However, the optimal conditions should be determined individually. The Phospho-c-Jun (Ser73) antibody detects only activated c-Jun when phosphorylated at Ser73. It does not react with |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
c-Jun is a component of the transcription factor AP-1 that binds and activates transcription at TRE/AP-1 elements. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73. Extracellular signals, such as growth factors and UV irradiation, stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun dependent transcription. The MAP kinase homologue, SAPK/JNK, binds to the N-terminal region of c-Jun and phosphorylates c-Jun at Ser63/73.
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Yanamadala V et al. (2007) J. Biol. Chem. 10.1074/jbc.M702804200.
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