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Phospho-BRCA1 (Ser1457) Antibody

Polyclonal antibody to detect endogenous levels of Phospho-BRCA1 (Ser1457)
Catalog #: A1719

In stock

$395.00

Product Details

Cat # +Size A1719-100
Size 100 µl
Antibody Target Breast cancer type 1 susceptibility protein
Alternate Name Breast cancer type 1 susceptibility protein, RING finger protein 53, RING-type E3 ubiquitin transferase BRCA1, RNF53
Host Rabbit
Antibody Type Polyclonal
Isotype IgG
Accession # P38398
Gene ID 672
Appearance Colorless liquid
Concentration 1mg/ml
Formulation In phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Affinity purified
Species Reactivity Human
Application Western Blotting, ELISA
Application & Usage WB 1:500-1:2000, ELISA (peptide) 1:20000-1:40000
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage.


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