Product Details
| Cat # +Size | A1012-100 |
|---|---|
| Size | 100µl |
| Antibody Target | Bcl-2 (Thr56) |
| Alternate Name | BCL2; Apoptosis regulator Bcl-2 |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | Synthesized peptide derived from human Bcl-2 around the phosphorylation site of Thr56 |
| Accession # | P10415 |
| Gene ID | 596 |
| Appearance | Colorless liquid |
| Concentration | 1mg/ml |
| Formulation | 100 ug (1mg/ml) of antibody in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide |
| Purification | Affinity purified rabbit IgG |
| Species Reactivity | Human |
| Application | WB, IHC, IP, IF, ELISA |
| Positive Control | Western blot |
| Application & Usage | WB 1:500-1:2000; IHC 1:100-1:300; IP 1:200-500; IF 1:200-1:1000; ELISA 1:20000 |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
The Bcl-2 family of proteins is the best characterized protein family involved in the regulation of apoptotic cell death in variety of cells. Bcl2 is an integral outer mitochondrial membrane protein that regulates mitochondrial calcium homeostasis and proton flux. Several reports suggested that these phosphorylation sites may be targets of the ASK1/MKK7/JNK1 pathway and that phosphorylation of Bcl-2 may be a marker for mitotic events. Mutation of Bcl-2 at Thr56 or S87 inhibits its anti-apoptotic activity during glucocorticoid-induced apoptosis of T lymphocytes.
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