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Phospho-Bcl-2 (Thr56) antibody

Polyclonal antibody to detect Bcl-2 (Phospho-Thr56) in human samples
Catalog #: A1012
$285.00

Product Details

Cat # +Size A1012-100
Size 100µl
Antibody Target Bcl-2 (Thr56)
Alternate Name BCL2; Apoptosis regulator Bcl-2
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthesized peptide derived from human Bcl-2 around the phosphorylation site of Thr56
Accession # P10415
Gene ID 596
Appearance Colorless liquid
Concentration 1mg/ml
Formulation 100 ug (1mg/ml) of antibody in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Purification Affinity purified rabbit IgG
Species Reactivity Human
Application WB, IHC, IP, IF, ELISA
Positive Control Western blot
Application & Usage WB 1:500-1:2000; IHC 1:100-1:300; IP 1:200-500; IF 1:200-1:1000; ELISA 1:20000
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The Bcl-2 family of proteins is the best characterized protein family involved in the regulation of apoptotic cell death in variety of cells. Bcl2 is an integral outer mitochondrial membrane protein that regulates mitochondrial calcium homeostasis and proton flux. Several reports suggested that these phosphorylation sites may be targets of the ASK1/MKK7/JNK1 pathway and that phosphorylation of Bcl-2 may be a marker for mitotic events. Mutation of Bcl-2 at Thr56 or S87 inhibits its anti-apoptotic activity during glucocorticoid-induced apoptosis of T lymphocytes.


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