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Phospho-AMPKβ1 (Ser182) Antibody

Polyclonal antibody to detect endogenous levels of AMPKβ1 protein when phosphorylated at Ser182 in human, mouse and rat.
Catalog #: A1248
$285.00

Product Details

Cat # +Size A1248-100
Size 100 µl
Antibody Target PRKAB1
Alternate Name PRKAB1; AMPK; 5'-AMP-activated protein kinase subunit beta-1; AMPK subunit beta-1; AMPKb
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthesized peptide derived from human AMPKβ1 around the phosphorylation site of S182.
Accession # Q9Y478
Gene ID 5564
Appearance Colorless liquid
Formulation In PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Purification Affinity-chromatography using epitope-specific immunogen
Species Reactivity Human, mouse , rat
Application WB, ELISA, IHC
Positive Control WB: COLO205 cell lysate
Application & Usage WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000
Handling The antibody solution should be gently mixed before use
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).


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