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Phospho-ALOX5 (Ser523) Antibody

Polyclonal antibody to detect endogenous levels of Phospho-ALOX5 (Ser523) in human and rat sample
Catalog #: A1714

In stock

$395.00

Product Details

Cat # +Size A1714-100
Size 100 µl
Antibody Target Arachidonate 5-lipoxygenase
Alternate Name ALOX5, 5-LOX, Arachidonate 5-lipoxygenase
Host Rabbit
Antibody Type Polyclonal
Isotype IgG
Accession # P09917
Gene ID 240
Appearance Colorless liquid
Concentration 1mg/ml
Formulation In phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Affinity purification
Species Reactivity Rat, Human
Application Immunofluorescence (IF), Immunocytochemistry (ICC), Western Blotting, ELISA
Application & Usage ELISA (peptide) 1:20000-1:40000, WB 1:500-1:2000, IF/ICC 1:100-1:500
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.


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