Product Details
| Cat # +Size | 1544-5 |
|---|---|
| Size | 5 mg |
| Alternate Name | PMA, 12-O-Tetradecanoylphorbol 13-acetate,TPA, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate |
| Appearance | White solid |
| CAS # | 16561-29-8 |
| Molecular Formula | C₃₆H₅₆O₈ |
| Molecular Weight | 616.83 |
| Purity | >99% |
| Solubility | DMSO or EtOH |
| SMILES | CCCCCCCCCCCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)C)O)C |
| InChi | InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1 |
| InChi Key | PHEDXBVPIONUQT-RGYGYFBISA-N |
| PubChem CID | 27924 |
| MDL Number | MFCD00036736 |
| Handling | Protect from light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
This is the most commonly used phorbol ester. It binds to and activates protein kinase C, causes an extremely wide range of effects in cells and tissues and is a very potent mouse skin tumor promoter. Inhibits apoptosis induced by the Fas antigen, but induced apoptosis in HL-60 promyelocytic leukemia cells
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Lu et al., IL-17A, But Not IL-17F, Is Indispensable for Airway Vascular Remodeling Induced by Exaggerated Th17 Cell Responses in Prolonged Ovalbumin-Challenged Mice. J. Immunol., Apr 2015; 194: 3557 - 3566.
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