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Phorbol-12-myristate 13-acetate (PMA)

based on 1 citations in multiple journalsPhorbol-12-myristate 13-acetate (PMA)14.1 4
A PKC activator
Catalog #: 1544
$150.00

Product Details

Cat # +Size 1544-5
Size 5 mg
Alternate Name PMA, 12-O-Tetradecanoylphorbol 13-acetate,TPA, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate
Appearance White solid
CAS # 16561-29-8
Molecular Formula C₃₆H₅₆O₈
Molecular Weight 616.83
Purity >99%
Solubility DMSO or EtOH
SMILES CCCCCCCCCCCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)C)O)C
InChi InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1
InChi Key PHEDXBVPIONUQT-RGYGYFBISA-N
PubChem CID 27924
MDL Number MFCD00036736
Handling Protect from light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

This is the most commonly used phorbol ester. It binds to and activates protein kinase C, causes an extremely wide range of effects in cells and tissues and is a very potent mouse skin tumor promoter. Inhibits apoptosis induced by the Fas antigen, but induced apoptosis in HL-60 promyelocytic leukemia cells


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Lu et al., IL-17A, But Not IL-17F, Is Indispensable for Airway Vascular Remodeling Induced by Exaggerated Th17 Cell Responses in Prolonged Ovalbumin-Challenged Mice. J. Immunol., Apr 2015; 194: 3557 - 3566.
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