Phorbol-12-myristate 13-acetate (PMA)

A PKC activator

Phorbol-12-myristate 13-acetate (PMA) is available from Abcam as ab120297.
Catalog #: 1544 | abID:

Product Details

Cat # +Size 1544-5
Size 5 mg
Alternate Name PMA, 12-O-Tetradecanoylphorbol 13-acetate,TPA, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate
Appearance White solid
CAS # 16561-29-8
Molecular Formula C₃₆H₅₆O₈
Molecular Weight 616.83
Purity >99%
Solubility DMSO or EtOH
InChi InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1
PubChem CID 27924
MDL Number MFCD00036736
Handling Protect from light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


This is the most commonly used phorbol ester. It binds to and activates protein kinase C, causes an extremely wide range of effects in cells and tissues and is a very potent mouse skin tumor promoter. Inhibits apoptosis induced by the Fas antigen, but induced apoptosis in HL-60 promyelocytic leukemia cells

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Lu et al., IL-17A, But Not IL-17F, Is Indispensable for Airway Vascular Remodeling Induced by Exaggerated Th17 Cell Responses in Prolonged Ovalbumin-Challenged Mice. J. Immunol., Apr 2015; 194: 3557 - 3566.
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