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Phleomycin

An antibiotic and selective agent
Catalog #: 2724
SKU-Size Size Price Qty
2724-5 5 mg
$95.00
2724-25 25 mg
$285.00
More Sizes Get Quote

Product Details

Alternate Name (2R,​3S,​4S,​5R,​6R)-​2-​(((2R,​3S,​4S,​5S,​6S)-​2-​(2-​(6-​amino-​2-​(3-​amino-​1-​((2,​3-​diamino-​3-​oxopropyl)amino)-​3-​oxopropyl)-​5-​methylpyrimidine-​4-​carboxamido)-​3-​((5-​((1-​((2-​(4-​((4-​guanidinobutyl)carbamoyl)-​4',​5'-​dihydro-​[2,​4'-​bithiazol]-​2'-​yl)ethyl)amino)-​3-​hydroxy-​1-​oxobutan-​2-​yl)amino)-​3-​hydroxy-​4-​methyl-​5-​oxopentan-​2-​yl)amino)-​1-​(1H-​imidazol-​4-​yl)-​3-​oxopropoxy)-​4,​5-​dihydroxy-​6-​(hydroxymethyl)tetrahydro-​2H-​pyran-​3-​yl)oxy)-​3,​5-​dihydroxy-​6-​(hydroxymethyl)tetrahydro-​2H-​pyran-​4-​yl carbamate,​ copper(II) salt,​ monohydrochloride
Appearance Light blue solid
CAS # 11006-33-0
Molecular Formula C₅₅H₈₅N₂₀O₂₁S₂Cu • HCl
Molecular Weight 1526.5
Purity ≥95%
Solubility H₂O (~ 20 mg/ml)
SMILES NC(O[[email protected]]1[[email protected]](O)[[email protected]@H](O[[email protected]@H]2[[email protected]](OC(C3=CNC=N3)C(NC(C4=NC(C(NCC(N)C(N)=O)CC(N)=O)=NC(N)=C4C)=O)C(NC(C(O)C(C)C(NC(C(O)C)C(NCCC5=NC(C6=NC(C(NCCCCNC(N)=N)=O)=CS6)CS5)=O)=O)C)=O)O[[email protected]@H](CO)[[email protected]@H](O)[[email protected]@H]2O)O[[email protected]](CO)[[email protected]]1[O-])=O.[H]Cl.[Cu+2]
InChi InChI=1S/C55H85N20O21S2.ClH.Cu/c1-19-32(72-45(75-43(19)58)24(11-30(57)79)67-12-23(56)44(59)85)49(89)74-34(40(25-13-63-18-68-25)94-53-42(38(83)36(81)28(14-76)93-53)95-52-39(84)41(96-55(62)91)37(82)29(15-77)92-52)50(90)69-21(3)35(80)20(2)46(86)73-33(22(4)78)48(88)65-10-7-31-70-27(17-97-31)51-71-26(16-98-51)47(87)64-8-5-6-9-66-54(60)61;;/h13,16,18,20-24,27-29,33-42,52-53,67,76-78,80-81,83-84H,5-12,14-15,17,56H2,1-4H3,(H2,57,79)(H2,59,85)(H2,62,91)(H,63,68)(H,64,87)(H,65,88)(H,69,90)(H,73,86)(H,74,89)(H2,58,72,75)(H4,60,61,66);1H;/q-1;;+2/t20?,21?,22?,23?,24?,27?,28-,29+,33?,34?,35?,36+,37+,38-,39-,40?,41+,42-,52+,53-;;/m0../s1
InChi Key XDWMLXOKMKKZFQ-LTUREVHFSA-N
MDL Number MFCD00131846
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Phleomycin is an antibiotic produced by Streptomyces verticullus and is structurally related to Bleomycin. Used as a selective agent in transformation experiments with mammalian cells, plant cells and yeast. Its cytotoxic action results from its ability to cause fragmentation of DNA. In Vitro studies indicate that Phleomycin causes accumulation of cells in the G2 phase of the cell cycle.


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