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PHA-680632

A potent inhibitor of Aurora kinases A, B, and C
Catalog #: B1944

In stock

SKU-Size Size Price Qty
B1944-5 5 mg
$185.00
B1944-25 25 mg
$725.00

Product Details

Alternate Name N-(2,6-diethylphenyl)-3-[[4-(4-methylpiperazin-1-yl)benzoyl]amino]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxamide
Appearance Crystalline solid
CAS # 398493-79-3
Molecular Formula C₂₈H₃₅N₇O₂
Molecular Weight 501.62
Purity ≥98% by HPLC
Solubility DMSO (>35 mg/ml)
SMILES CCC1=C(C(=CC=C1)CC)NC(=O)N2CC3=C(C2)NN=C3NC(=O)C4=CC=C(C=C4)N5CCN(CC5)C
InChi InChI=1S/C28H35N7O2/c1-4-19-7-6-8-20(5-2)25(19)29-28(37)35-17-23-24(18-35)31-32-26(23)30-27(36)21-9-11-22(12-10-21)34-15-13-33(3)14-16-34/h6-12H,4-5,13-18H2,1-3H3,(H,29,37)(H2,30,31,32,36)
InChi Key OBWNXGOQPLDDPS-UHFFFAOYSA-N
PubChem CID 11249084
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PHA-680632 is potent inhibitor of Aurora kinases A, B, and C with IC₅₀ values of of 27 nM, 135 nM and 120 nM, respectively. It displays weaker selectivity for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3.


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