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PH-797804

A potent and selective P38 MAPK inhibitor
Catalog #: B1707
SKU-Size Size Price Qty
B1707-5 5 mg
$125.00
B1707-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name PH-797804; PH797804; PH 797804; 3-[3-bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxopyridin-1-yl]-N,4-dimethylbenzamide; 3-(4-(2,4-difluorobenzyloxy)-3-bromo-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide
Appearance Solid
CAS # 586379-66-0
Molecular Formula C₂₂H₁₉BrF₂N₂O₃
Molecular Weight 477.3
Purity >98%
Solubility DMSO
SMILES CC1=C(C=C(C=C1)C(=O)NC)N2C(=CC(=C(C2=O)Br)OCC3=C(C=C(C=C3)F)F)C
InChi InChI=1S/C22H19BrF2N2O3/c1-12-4-5-14(21(28)26-3)9-18(12)27-13(2)8-19(20(23)22(27)29)30-11-15-6-7-16(24)10-17(15)25/h4-10H,11H2,1-3H3,(H,26,28)
InChi Key KCAJXIDMCNPGHZ-UHFFFAOYSA-N
PubChem CID 22049997
MDL Number MFCD18251426
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PH-797804 is a novel pyridinone inhibitor of p38α with IC50 of 26 nM; 4-fold more selective versus p38β.


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