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PFK-158

PFK-2/FBPase inhibitor
Catalog #: B2515
SKU-Size Size Price Qty
B2515-5 5 mg
$95.00
B2515-25 25 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name N4-isobutyl-N2-((2-phenylthiazol-4-yl)methyl)pyrimidine-2,4-diamine
Appearance White to off-white solid
CAS # 1462249-75-7
Molecular Formula C₁₈H₁₁F₃N₂O
Molecular Weight 328.29
Purity ≥98% by HPLC
Solubility >30 mg/ml in DMSO
SMILES C1=CC(=CC2=C1C=CC(=N2)C=CC(=O)C3=CC=NC=C3)C(F)(F)F
InChi InChI=1S/C18H11F3N2O/c19-18(20,21)14-3-1-12-2-4-15(23-16(12)11-14)5-6-17(24)13-7-9-22-10-8-13/h1-11H/b6-5+
InChi Key IAJOMYABKVAZCN-AATRIKPKSA-N
PubChem CID 71730058
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PFK158 is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3; IC₅₀ = 137 nM for human recombinant PFKFB3). Upon administration, PFK-158 binds to and inhibits the activity of PFKFB3, which leads to the inhibition of both the glycolytic pathway in and glucose uptake by cancer cells.


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