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PFI-3

A potent and selective polybromo 1 and SMARCA4 inhibitor
Catalog #: 2895
SKU-Size Size Price Qty
2895-5 5 mg
$145.00
2895-25 25 mg
$575.00
More Sizes Get Quote

Product Details

Alternate Name (E)-1-(2-Hydroxyphenyl)-3-((1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)prop-2-en-1-one
Appearance Yellow solid
Molecular Formula C₁₉H₁₉N₃O₂
Molecular Weight 321.37
Purity ≥98% by HPLC
Solubility DMSO (> 30 mg/ml) or EtOH (>30 mg/ml)
SMILES C1C2CN(C1CN2C3=CC=CC=N3)C=CC(=O)C4=CC=CC=C4O
InChi InChI=1S/C19H19N3O2/c23-17-6-2-1-5-16(17)18(24)8-10-21-12-15-11-14(21)13-22(15)19-7-3-4-9-20-19/h1-10,14-15,23H,11-13H2/b10-8+/t14-,15-/m1/s1
InChi Key INAICWLVUAKEPB-QSTFCLMHSA-N
PubChem CID 78243717
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PFI-3 is a potent and selective polybromo 1 (PB1) and SMARCA4 (SWI/SNF related, Matrix associated, Actin dependent Regulator of Chromatin, subfamily A, member 4) inhibitor (Kd values are 48 and 89 nM respectively). SMARCA4, also known as BRG1 (Brahma-Related Gene1), is part of the SWI/SNF (SWItch/Sucrose Non-Fermentable) family of proteins. Loss of function of SMARCA4 and components of SWI/SNF has been linked to cancer development suggesting a tumour suppressor function for BRG1. SMARCA4 has also been shown to interact with the breast cancer gene BRCA1 (BReast CAncer 1, early onset), as well as to regulate the expression of the tumorigenic protein CD44.


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