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PFI-2

A potent and selective SETD7 histone lysine methyltransferase inhibitor
Catalog #: B1259
SKU-Size Size Price Qty
B1259-5 5 mg
$115.00
B1259-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name (R)-8-fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide
Peptide Sequence N/A
Appearance Crystaline solid
Formulation N/A
CAS # 1627676-59-8
Molecular Formula C₂₃H₂₅F₄N₃O₃S
Molecular Weight 499.52
Purity ≥98% by HPLC
Solubility DMSO (>30 mg/ml)
SMILES C1CCN(C1)C(=O)C(CC2=CC(=CC=C2)C(F)(F)F)NS(=O)(=O)C3=CC(=C4CNCCC4=C3)F
InChi InChI=1S/C23H25F4N3O3S/c24-20-13-18(12-16-6-7-28-14-19(16)20)34(32,33)29-21(22(31)30-8-1-2-9-30)11-15-4-3-5-17(10-15)23(25,26)27/h3-5,10,12-13,21,28-29H,1-2,6-9,11,14H2/t21-/m1/s1
InChi Key JCKGSPAAPQRPBW-OAQYLSRUSA-N
PubChem CID 71300326
MDL Number N/A
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PFI-2 is a novel potent and selective SETD7 histone lysine methyltransferase inhibitor (IC₅₀ ~2 nM). It has > 100-fold selectivity over other methyltransferases and other non-epigenetic targets. PFI-2 has been shown to bind to SETD7 by ITC (Kd = 18 nM), and biotinylated PFI-2 interacts with SETD7 in pull-down studies.


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