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An allosteric human methionine adenosyltransferase 2A (Mat2A) inhibitor
Catalog #: B2244
SKU-Size Size Price Qty
B2244-5 5 mg
B2244-25 25 mg
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Product Details

Alternate Name 2-(7-Chloro-5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)-N,N-dimethylethan-1-amine
Appearance White to off-white solid
CAS # 72882-78-1
Molecular Formula C₂₀H₁₉ClN₄
Molecular Weight 350.85
Purity ≥98% by HPLC
Solubility DMSO
InChi InChI=1S/C20H19ClN4/c1-24(2)11-10-19-22-23-20-13-16(14-6-4-3-5-7-14)17-12-15(21)8-9-18(17)25(19)20/h3-9,12-13H,10-11H2,1-2H3
PubChem CID 12612431
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


PF-9366 is an allosteric inhibitor of human methionine adenosyltransferase 2A (Mat2A), the extrahepatic isoform (IC₅₀ = 420 nM). PF-9366 inhibits cellular S-Adenosyl-L-methionine (SAM) production with an IC₅₀ of 1.2 μM in H520 lung carcinoma cells.

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