Product Details
| abID | ab287062 |
|---|---|
| Alternate Name | N-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methyl-4-piperidinyl]-N'-(4-cyanophenyl)-urea |
| Appearance | Crystalline solid |
| CAS # | 1095173-27-5 |
| Molecular Formula | C₂₁H₂₂N₆O |
| Molecular Weight | 374.4 |
| Purity | ≥98% by HPLC |
| Solubility | ~20 mg/ml DMSO |
| SMILES | CN1CCC(CC1C2=NC3=CC=CC=C3N2)NC(=O)NC4=CC=C(C=C4)C#N |
| InChi | InChI=1S/C21H22N6O/c1-27-11-10-16(24-21(28)23-15-8-6-14(13-22)7-9-15)12-19(27)20-25-17-4-2-3-5-18(17) 26-20/h2-9,16,19H,10-12H2,1H3,(H,25,26)(H2,23,24,28)/t16-,19-/m1/s1 |
| InChi Key | SFNSLLSYNZWZQG-VQIMIIECSA-N |
| PubChem CID | 25166913 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
PF-04449913 is a potent and orally bioavailable smoothened (SMO) inhibitor. PF-04449913 binds to human SMO with an IC₅₀ of 4 nM. It has been shown to attenuate leukemia stem cell self-renewal and cell cycle progression in primary acute myeloid leukemia cells and in an in vivo Drosophila model.
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