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A potent, brain-penetrant and selective PDE9 (Phosphodiesterase 9) inhibitor
Catalog #: B1264
SKU-Size Size Price Qty
B1264-5 5 mg
B1264-25 25 mg
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Product Details

Alternate Name  N-[2-(diethylamino)ethyl]-2-[[(4-fluorophenyl)methyl]thio]-4,5,6,7-tetrahydro-4-oxo-N-[[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methyl]-1H-Cyclopentapyrimidine-1-acetamide; SB-480848
Appearance Crystaline solid
CAS # 1082744-20-4
Molecular Formula C₂₀H₂₅N₇O₂
Molecular Weight 395.46
Purity ≥98% by HPLC
Solubility DMSO
InChi InChI=1S/C20H25N7O2/c1-13-10-26(12-17-21-5-2-6-22-17)11-16(13)18-24-19-15(20(28)25-18)9-23-27(19)14-3-7-29-8-4-14/h2,5-6,9,13-14,16,23H,3-4,7-8,10-12H2,1H3/t13-,16-/m1/s1
PubChem CID 25115162
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


PF-04447943 is a potent, brain-penetrant and selective inhibitor of PDE9 (Phosphodiesterase 9) (Ki of 2.8, 4.5 and 18 nM for human, rhesus and rat recombinant PDE9 respectively). Displays high selectivity for PDE9 versus PDEs1-8 and 10-11.

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