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An ATP-competitive inhibitor of Aurora kinases A and B
Catalog #: B1257
SKU-Size Size Price Qty
B1257-5 5 mg
B1257-25 25 mg
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Product Details

Alternate Name N-[2-[(1S,4R)-6-[[4-(Cyclobutylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1,2,3,4-tetrahydronaphthalen-1,4-imin-9-yl]-2-oxoethyl]-acetamide
Appearance White solid
CAS # 942487-16-3
Molecular Formula C₂₃H₂₅F₃N₆O₂
Molecular Weight 474.48
Purity ≥98% by HPLC
Solubility DMSO (>40 mg/ml)
InChi InChI=1S/C23H25F3N6O2/c1-12(33)27-11-20(34)32-18-7-8-19(32)16-9-14(5-6-15(16)18)30-22-28-10-17(23(24,25)26)21(31-22)29-13-3-2-4-13/h5-6,9-10,13,18-19H,2-4,7-8,11H2,1H3,(H,27,33)(H2,28,29,30,31)
PubChem CID 49830590
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


PF-03814735 is an ATP-competitive inhibitor of Aurora kinases A and B with IC₅₀values of 0.8 and 0.5 nM respectively. It has shown to block cytokinesis, inhibit cellular proliferation in many tumor cell lines including HCT-116, HL-60 and A549. In vitro experiments have shown that PF 03814735 inhibits the phosphorylation of Aurora B H3 and Aurora A cultured MDA-MB-231 cells.

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