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PF-04965842

A potent Janus Kinase 1 (JAK1) inhibitor
Catalog #: B2470

In stock

SKU-Size Size Price Qty
B2470-5 5 mg
$115.00
B2470-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name N-((1s,3s)-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclobutyl)propane-1-sulfonamide; PF04965842; Abrocitinib
Appearance Crystalline solid
CAS # 1622902-68-4
Molecular Formula C₁₄H₂₁N₅O₂S
Molecular Weight 323.42
Purity ≥98% by HPLC
Solubility >10 mg/ml DMSO
SMILES CCCS(=O)(=O)NC1CC(C1)N(C)C2=NC=NC3=C2C=CN3
InChi InChI=1S/C14H21N5O2S/c1-3-6-22(20,21)18-10-7-11(8-10)19(2)14-12-4-5-15-13(12)16-9-17-14/h4-5,9-11,18H,3,6-8H2,1-2H3,(H,15,16,17)
InChi Key IUEWXNHSKRWHDY-UHFFFAOYSA-N
PubChem CID 78323835
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PF-04965842 (Abrocitinib) is a potent, selective, orally bioavailable JAK1 inhibitor (IC₅₀ = 29 nM). It displays excellent selectivity for JAK1 versus other JAK family enzymes.


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