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PF-670462

A potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor
Catalog #: B2271
SKU-Size Size Price Qty
B2271-5 5 mg
$125.00
B2271-25 25 mg
$475.00
More Sizes Get Quote

Product Details

Alternate Name 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine dihydrochloride
Appearance Off-white solid
CAS # 950912-80-8
Molecular Formula C₁₉H₂₀FN₅.2HCl
Molecular Weight 410.32
Purity ≥98% by HPLC
Solubility DMSO (>35 mg/ml) or H2O (>35 mg/ml)
SMILES C1CCC(CC1)N2C=NC(=C2C3=NC(=NC=C3)N)C4=CC=C(C=C4)F.Cl.Cl
InChi InChI=1S/C19H20FN5.2ClH/c20-14-8-6-13(7-9-14)17-18(16-10-11-22-19(21)24-16)25(12-23-17)15-4-2-1-3-5-15;;/h6-12,15H,1-5H2,(H2,21,22,24);2*1H
InChi Key PSNKGVAXBSAHCH-UHFFFAOYSA-N
PubChem CID 51049607
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PF-670462 is a potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC₅₀ values are 7.7 and 14 nM respectively) that displays > 30-fold selectivity over 42 other kinases. Inhibits PER protein nuclear translocation (EC₅₀ = 290 nM) causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion in vivo.


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