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A checkpoint kinase 1 (CHk1) inhibitor
Catalog #: B2335
SKU-Size Size Price Qty
B2335-5 5 mg
B2335-25 25 mg
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Product Details

Alternate Name (R)-α-Amino-N-[5,6-dihydro-2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-1H-pyrrolo[4,3,2-ef][2,3]benzodiazepin-8-yl]-cyclohexaneacetamide
Appearance Yellow solid
CAS # 952021-60-2
Molecular Formula C₂₂H₂₅N₇O₂
Molecular Weight 419.48
Purity ≥98% by HPLC
Solubility >30 mg/ml (DMSO)
InChi InChI=1S/C22H25N7O2/c1-29-11-13(9-25-29)20-16-10-24-28-21(30)15-7-14(8-17(27-20)18(15
PubChem CID 16750408
MDL Number MFCD16038847
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


PF-477736 is a potent, ATP-competitive inhibitor of Chk1 (checkpoint kinase 1) (Ki =0.49 nM). It displays 100-fold selectivity over Chk2. PF-477736 abrogates DNA damage-induced cell cycle arrest.

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