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PF-3758309

A p21-activated kinase 4 (PAK4) inhibitor
Catalog #: B2634
SKU-Size Size Price Qty
B2634-5 5 mg
$115.00
B2634-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name PF-03758309 PF3758309 PF03758309 (S)-N-(2-(dimethylamino)-1-phenylethyl)-6,6-dimethyl-3-((2-methylthieno[3,2-d]pyrimidin-4-yl)amino)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide
Appearance White to off-white solid
CAS # 898044-15-0
Molecular Formula C₂₅H₃₀N₈OS
Molecular Weight 490.62
Purity ≥98% by HPLC
Solubility ~10 mg/ml in DMSO
SMILES CC1=NC2=C(C(=N1)NC3=NNC4=C3CN(C4(C)C)C(=O)NC(CN(C)C)C5=CC=CC=C5)SC=C2
InChi InChI=1S/C25H30N8OS/c1-15-26-18-11-12-35-20(18)23(27-15)29-22-17-13-33(25(2,3)21(17)30-31-22)24(34)28-19(14-32(4)5)16-9-7-6-8-10-16/h6-12,19H,13-14H2,1-5H3,(H,28,34)(H2,26,27,29,30,31)/t19-/m1/s1
InChi Key AYCPARAPKDAOEN-LJQANCHMSA-N
PubChem CID 25227462
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PF-3758309 is a potent small molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PF-3758309 binds to PAK4, inhibiting PAK4 activity and cancer cell growth. PAK4, a serine/threonine kinase belonging to the p21-activated kinase (PAK) family, is often upregulated in a variety of cancer cell types and plays an important role in cancer cell motility, proliferation, and survival.


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