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PF-06821497

A potent Histone Methyltransferase (HMT) EZH2 inhibitor
Catalog #: B3323
SKU-Size Size Price Qty
B3323-1 1 mg
$95.00
B3323-5 5 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name PF06821497 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1-one
Appearance Solid
CAS # 1844849-10-0
Molecular Formula C₂₂H₂₄Cl₂N₂O₅
Molecular Weight 467.34
Purity ≥98%
Solubility DMSO
SMILES COC1=C(CN2CCC(C(Cl)=CC([[email protected]](OC)C3COC3)=C4Cl)=C4C2=O)C(NC(C)=C1)=O
InChi InChI=1S/C22H24Cl2N2O5/c1-11-6-17(29-2)15(21(27)25-11)8-26-5-4-13-16(23)7-14(19(24)18(13)22(26)28)20(30-3)12-9-31-10-12/h6-7,12,20H,4-5,8-10H2,1-3H3,(H,25,27)/t20-/m1/s1
InChi Key RXCVUHMIWHRLDF-HXUWFJFHSA-N
PubChem CID 118572065
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PF-06821497 is a potent and selective EZH2 (Enhancer of Zeste Homolog 2) inhibitor, inhibiting the activities of both wild-type (Ki = 0.3nM) and mutant (Y641N) (Ki < 0.1nM). Displays robust tumor growth inhibition.


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