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Product Details
| Alternate Name | 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic acid |
|---|---|
| Appearance | Off-white solid |
| CAS # | 1467057-23-3 |
| Molecular Formula | C₁₉H₁₆ClNO₃ |
| Molecular Weight | 341.79 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (>40 mg/ml) |
| SMILES | C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=C3)C(=CN4)C(=O)O)Cl)O |
| InChi | InChI=1S/C19H16ClNO3/c20-16-9-17-14(15(10-21-17)18(22)23)8-13(16)11-2-4-12(5-3-11)19(24)6-1-7-19/h2-5,8-10,21,24H,1,6-7H2,(H,22,23) |
| InChi Key | FHQXLWCFSUSXBF-UHFFFAOYSA-N |
| PubChem CID | 71748255 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
PF-06409577 is a potent and selective allosteric activator of AMPK (EC₅₀ values are 7 and >40000 nM for AMPKα1β1γ1 and AMPKα1β2γ1, respectively). Displays minimal off-target effects on a panel of receptors, ion channels, PDEs and kinases. Shows efficacy in a preclinical model of diabetic nephropathy.
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