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PF-06409577

A potent and selective allosteric AMPK activator
Catalog #: B2033

In stock

SKU-Size Size Price Qty
B2033-5 5 mg
$185.00
B2033-25 25 mg
$695.00
More Sizes Get Quote

Product Details

Alternate Name 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic acid
Appearance Off-white solid
CAS # 1467057-23-3
Molecular Formula C₁₉H₁₆ClNO₃
Molecular Weight 341.79
Purity ≥98% by HPLC
Solubility DMSO (>40 mg/ml)
SMILES C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=C3)C(=CN4)C(=O)O)Cl)O
InChi InChI=1S/C19H16ClNO3/c20-16-9-17-14(15(10-21-17)18(22)23)8-13(16)11-2-4-12(5-3-11)19(24)6-1-7-19/h2-5,8-10,21,24H,1,6-7H2,(H,22,23)
InChi Key FHQXLWCFSUSXBF-UHFFFAOYSA-N
PubChem CID 71748255
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PF-06409577 is a potent and selective allosteric activator of AMPK (EC₅₀ values are 7 and >40000 nM for AMPKα1β1γ1 and AMPKα1β2γ1, respectively). Displays minimal off-target effects on a panel of receptors, ion channels, PDEs and kinases. Shows efficacy in a preclinical model of diabetic nephropathy.


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