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PF-03394197

A potent and selective JAK inhibitor
Catalog #: 2883
SKU-Size Size Price Qty
2883-5 5 mg
$145.00
2883-25 25 mg
$575.00
More Sizes Get Quote

Product Details

Alternate Name N-Methyl-1-((1r,4r)-4-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)methanesulfonamide; Oclacitinib
Appearance White to off-white solid
CAS # 1208319-26-9
Molecular Formula C₁₅H₂₃N₅O₂S
Molecular Weight 337.44
Purity ≥98% by HPLC
Solubility DMSO (>30 mg/ml)
SMILES CNS(=O)(=O)CC1CCC(CC1)N(C)C2=NC=NC3=C2C=CN3
InChi InChI=1S/C15H23N5O2S/c1-16-23(21,22)9-11-3-5-12(6-4-11)20(2)15-13-7-8-17-14(13)18-10-19-15/h7-8,10-12,16H,3-6,9H2,1-2H3,(H,17,18,19)
InChi Key HJWLJNBZVZDLAQ-UHFFFAOYSA-N
PubChem CID 44631938
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PF-03394197 is potent and selective Janus kinase (JAK) inhibitor. It inhibits JAK family members with an IC₅₀ of 10-99 nM being most potent against JAK1 (IC₅₀ = 10 nM). PF-03394197 does not inhibit a panel of 38 non-JAK kinases (IC₅₀ >1 µM). Displays activity against cytokines involved in allergy.


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