Product Details
| abID | ab142055 |
|---|---|
| Alternate Name | KRX-0401 |
| Appearance | White to off-white solid |
| CAS # | 157716-52-4 |
| Molecular Formula | C₂₅H₅₃NO₄P |
| Molecular Weight | 462.66 |
| Purity | ≥99% |
| Solubility | H₂O (10 mg/ml) |
| SMILES | CCCCCCCCCCCCCCCCCCOP(=O)(O)OC1CC[N+](CC1)(C)C |
| InChi | InChI=1S/C25H52NO4P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24-29-31(27,28)30-25-20-22-26(2,3)23-21-25/h25H,4-24H2,1-3H3/p+1 |
| InChi Key | SZFPYBIJACMNJV-UHFFFAOYSA-O |
| PubChem CID | 148178 |
| MDL Number | MFCD00927554 |
| Handling | Protect from light and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Belongs to an alkylphospholipid class of antineoplastic compounds that display potent antiproliferative activity in several in vitro and in vivo human tumor models. Perifosine induces apoptotic cell death in a variety of tumor cell lines. Apoptosis is induced in a time- and dose-dependent manner in U937 and Jurkat T human leukemia cell lines but not in normal vascular endothelial cells.
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Alison Maddigan et al., EphB Receptors Trigger Akt Activation and Suppress Fas Receptor-Induced Apoptosis in Malignant T Lymphocytes J. Immunol., Dec 2011; 187: 5983 - 5994.
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