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Perifosine (KRX-0401)

based on 1 citations in multiple journalsPerifosine (KRX-0401)14.1 4
An antineoplastic agent
Catalog #: 1592
SKU-Size Size Price Qty
1592-5 5 mg
$205.00
1592-25 25 mg
$625.00
More Sizes Get Quote

Product Details

Alternate Name KRX-0401
Appearance White to off-white solid
CAS # 157716-52-4
Molecular Formula C₂₅H₅₃NO₄P
Molecular Weight 462.66
Purity ≥99%
Solubility H₂O (10 mg/ml)
SMILES CCCCCCCCCCCCCCCCCCOP(=O)(O)OC1CC[N+](CC1)(C)C
InChi InChI=1S/C25H52NO4P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24-29-31(27,28)30-25-20-22-26(2,3)23-21-25/h25H,4-24H2,1-3H3/p+1
InChi Key SZFPYBIJACMNJV-UHFFFAOYSA-O
PubChem CID 148178
MDL Number MFCD00927554
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Belongs to an alkylphospholipid class of antineoplastic compounds that display potent antiproliferative activity in several in vitro and in vivo human tumor models. Perifosine induces apoptotic cell death in a variety of tumor cell lines. Apoptosis is induced in a time- and dose-dependent manner in U937 and Jurkat T human leukemia cell lines but not in normal vascular endothelial cells.


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Alison Maddigan et al., EphB Receptors Trigger Akt Activation and Suppress Fas Receptor-Induced Apoptosis in Malignant T Lymphocytes J. Immunol., Dec 2011; 187: 5983 - 5994.
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