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Penicillin G Potassium

A broad-spectrum β-lactam antibiotic
Catalog #: B3131
SKU-Size Size Price Qty
B3131-10G 10 g
$65.00
B3131-50G 50 g
$195.00
More Sizes Get Quote

Product Details

Alternate Name Benzylpenicillin potassium; potassium;(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
Appearance White to off-white powder
CAS # 113-98-4
Molecular Formula C₁₆H₁₇KN₂O₄S
Molecular Weight 372.5
Purity ≥ 98%
Solubility ~100 mg/ml in water
SMILES CC1(C(N2C(S1)C(C2=O)NC(=O)CC3=CC=CC=C3)C(=O)[O-])C.[K+]
InChi InChI=1S/C16H18N2O4S.K/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1
InChi Key IYNDLOXRXUOGIU-LQDWTQKMSA-M
PubChem CID 23664709
MDL Number MFCD00036193
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions 4ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Penicillin is a broad-spectrum β-lactam antibiotic. It binds to penicillin binding proteins (PBP). PBP catalyzes the synthesis of peptidoglycan, which is an important component of the bacterial cell wall. PBP catalyzes a pentaglycine crosslink between the alanine and lysine residues providing additional strength to the cell wall. The integrity of the cell wall is severely compromised without a pentaglycine crosslink, which leads to cell lysis and death. Penicillin G shows MIC₉₀ values of 0.03, 1 and 4 µg/ml for penicillin-susceptible, -intermediate and -resistant strains of S. pneumoniae, respectively. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.


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