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Pemetrexed

A high affinity dihydrofolate reductase (DHFR) inhibitor
Catalog #: B1862

In stock

SKU-Size Size Price Qty
B1862-50 50 mg
$95.00
B1862-250 250 mg
$285.00

Product Details

Alternate Name N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid
Appearance White solid
CAS # 137281-23-3
Molecular Formula C₂₀H₂₁N₅O₆
Molecular Weight 427.41
Purity ≥98% by HPLC
Solubility DMSO (>40 mg/ml)
SMILES C1=CC(=CC=C1CCC2=CNC3=C2C(=O)N=C(N3)N)C(=O)NC(CCC(=O)O)C(=O)O
InChi InChI=1S/C20H21N5O6/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29)/t13-/m0/s1
InChi Key WBXPDJSOTKVWSJ-ZDUSSCGKSA-N
PubChem CID 446556
MDL Number MFCD19105065
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Pemetrexed is a high affinity dihydrofolate reductase (DHFR) inhibitor (Ki = 7 nM). Also inhibits thymidylate synthase, AICART and glycinamide ribonucleotide formyltransferase (Ki values are 109 nM, and 3.5 μM and 9.3 μM, respectively). Inhibits proliferation of cancer cell lines in vitro.


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