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Peficitinib

A potent JAK inhibitor
Catalog #: B2474
SKU-Size Size Price Qty
B2474-1 1 mg
$75.00
B2474-5 5 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name ASP015K; 4-(((1R,2r,3S,5s,7s)-5-hydroxyadamantan-2-yl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide; JNJ 54781532; JNJ-54781532
Appearance Crystalline solid
CAS # 944118-01-8
Molecular Formula C₁₈H₂₂N₄O₂
Molecular Weight 326.4
Purity ≥98% by HPLC
Solubility >50 mg/ml DMSO
SMILES C1C2CC3CC(C2)(CC1C3NC4=C5C=CNC5=NC=C4C(=O)N)O
InChi InChI=1S/C18H22N4O2/c19-16(23)13-8-21-17-12(1-2-20-17)15(13)22-14-10-3-9-4-11(14)7-18(24,5-9)6-10/h1-2,8-11, 14,24H,3-7H2,(H2,19,23)(H2,20,21,22)/t9?,10-,11+,14?,18?
InChi Key DREIJXJRTLTGJC-JQCLMNFQSA-N
PubChem CID 57928403
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

eficitinib is a potent JAK inhibitor, with IC₅₀s of 3.9, 5.0, 0.7 and 4.8 nM for JAK1, JAK2, JAK3 and Tyk2, respectively. Peficitinib inhibits IL-2-induced proliferation of rat splenocytes (IC₅₀ = 10 nM) and phosphorylation of STAT5 in rat and human whole blood (IC₅₀s = 124 and 127 nM, respectively).


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