PEDF, human recombinant

A multifunctional protein with anti-angiogenic, anti-tumorigenic, and neurotrophic functions
Catalog #: 4988 | abID:

Product Details

Alternate Name Pigment epithelium-derived factor, PEDF, Serpin-F1, SerpinF1, EPC-1, EPC1, PIG35
Gene Symbol PEDF
Gene ID 5176
Accession # P36955
Source E. coli
Appearance Lyophilized protein
Physical Form Description The sterile filtered concentrated (1 mg/ml) protein solution was lyophilized with 20 mM PBS & 150 mM NaCl pH-7.4.
Molecular Weight 44.5 kDa
Purity by SDS-PAGE ≥95%
Purity by ≥95%
Endotoxin Level <0.1 ng/μg
Biological Activity Not available at this time
Reconstitution Instructions The sterile filtered concentrated (1 mg/ml) protein solution was lyophilized with 20 mM phosphate buffer & 150 mM NaCl pH-7.4.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
USAGE For Research Use Only! Not to be used in humans

Details

PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. PEDF is a 50,000 dalton glycoprotein created and secreted in many tissues all the way through the body. A key component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. Additionally, PEDF is capable to inhibit the activity of angiogenic factors such as VEGF and FGF-2. The recognition of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. The unique range of PEDF activities associate it as a potential therapeutic agent for the treatment of vasculature related neurodegenerative diseases such as age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR). PEDF in addition has the potential to be functional in the treatment of various angiogenesis-related diseases including a number of cancers. Recombinant human PEDF produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 400 amino acids and having a molecular mass of 44.5 kDa.


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