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PDTC

based on 1 citations in multiple journalsPDTC14.1 4
A NF-kappaB inhibitor
Catalog #: 1676
$80.00

Product Details

Cat # +Size 1676-100
Size 100 mg
Alternate Name Pyrrolidinedithiocarbamate Ammonium; PDC; APDC
Appearance White solid
CAS # 5108-96-3
Molecular Formula C₅H₉NS₂.NH₃
Molecular Weight 164.28
Purity ≥98%
Solubility DMSO (15 mg/ml) and H₂O (1 mg/ml)
SMILES C1CCN(C1)C(=S)[S-].[NH4+]
InChi InChI=1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3
InChi Key MDDIUTVUBYEEEM-UHFFFAOYSA-N
PubChem CID 517348
MDL Number MFCD00012720
Handling Protect from air and moisture
Storage Conditions 4°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

An antioxidant and an inhibitor of NF-kB; prevents induction of nitric oxide synthase (NOS) by inhibiting translation of NOS mRNA; induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells. Also inhibits breast cancer stem-like cells by blocking the NF-kB activity in MCF7 sphere and MCF7 cells.


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Zhang, L.W et al. (2016) Interleukin-17 Impairs Salivary Tight Junction Integrity in Sjögren's Syndrome. J Dent Res. 2016 Jul;95(7):784-92.
Li et al., Activation of decidual invariant natural killer T cells promotes lipopolysaccharide-induced preterm birth. Mol. Hum. Reprod., Apr 2015; 21: 369 - 381.
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