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PDGFR beta, Active

Important factors regulating cell proliferation, cellular differentiation, cell growth and development
Catalog #: 7770
$295.00

Product Details

Cat # +Size 7770-5
Size 5 μg
Alternate Name PDGR. platelet-derived growth factor receptor, beta polypeptide
Gene Symbol PDGFRB
Gene ID 5159
Accession # NM_002609.
Source Baculovirus (Sf9 insect cells)
Appearance Liquid
Physical Form Description Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Molecular Weight 96.0 kDa
Purity by SDS-PAGE ≥90%
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

PDGFRb (platelet-derived growth factor receptor b) is a member of the PDGFR family of membrane receptors with intrinsic tyrosine kinase activity. PDGFRb deficient mice are hemorrhagic, severely anemic and exhibit a defect in kidney glomeruli function (1). However, absence of PDGFRb has no impact on major blood vessels and the heart. PDGFRb expression and activity is elevated in several cancers and inhibition of PDGFRb activity blocks progression of renal carcinoma in an animal model (2).


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