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PDGFR Antibody (Clone # 275CT1)

Monoclonal Antibody to detect PDGFR in human samples.
Catalog #: 6787
$245.00

Product Details

Cat # +Size 6787-50
Size 50 μl
Antibody Target PDGFR
Alternate Name PDGFRB; PDGFR; PDGFR1; Platelet-derived growth factor receptor beta; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; Platelet-derived growth factor receptor 1
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG1, k
Immunogen Purified His-tagged PDGFR protein (Fragment) was used to produce this monoclonal antibody.
Accession # P16234
Gene ID 5156
Appearance Colorless liquid
Formulation Crude ascites with 0.09% (W/V) sodium azide.
Species Reactivity Mouse.
Application Western blot.
Positive Control Western blot: NIH-3TY3 cell lysate.
Application & Usage WB: 1:500 – 1:16000.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Platelet-derived growth factor (PDGF) refers to a family of disulphide-bonded dimeric isoforms that are important for growth and survival, and which function in several types of connective tissue cell. There are four members of the platelet-derived growth factor (PDGF) family: PDGF-A, PDGF-B, PDGF-C and PDGF-D (spinal cord-derived growth factor-B or iris-expressed growth factor). Their biological effects are mediated via two tyrosine kinase receptors, PDGFR-α and PDGFR-β. PDGF-mediated signaling is critical for development of many organ systems. PDGF-D has a two-domain structure similar to PDGF-C and is secreted as a disulphide-linked homodimer, PDGF-DD. Upon limited proteolysis, PDGF-DD is activated and becomes a specific agonistic ligand for PDGFR-β. PDGF-D is expressed in fibroblastic adventitial cells, cultured endothelial cells and in a variety of tumor cell lines.


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