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PD 98059

based on 1 citations in multiple journalsPD 9805914.1 4
A MEK inhibitor
Catalog #: 1666
$100.00

Product Details

Cat # +Size 1666-5
Size 5 mg
Alternate Name 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
Appearance Yellow solid
CAS # 167869-21-8
Molecular Formula C₁₆H₁₃NO₃
Molecular Weight 267.28
Purity ≥98% by HPLC
Solubility DMSO (25 mM) or EtOH(5 mM)
SMILES COC1=CC=CC(=C1N)C2=CC(=O)C3=CC=CC=C3O2
InChi InChI=1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3
InChi Key QFWCYNPOPKQOKV-UHFFFAOYSA-N
PubChem CID 4713
MDL Number MFCD00671789
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent, selective and cell-permeable inhibitor of MAP kinase kinase (MEK). It inhibits phosphorylation of MAP kinase by MEK. PD 98059 does not inhibit MAP kinase itself.


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Noda et al., Cigarette smoke impairs phagocytosis of apoptotic neutrophils by alveolar macrophages via inhibition of the histone deacetylase/Rac/CD9 pathways. Int. Immunol., Nov 2013; 25: 643 - 650.
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