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PD-166285 dihydrochloride

A potent, ATP-competitive and broadly active protein tyrosine kinase inhibitor
Catalog #: B2094

In stock

SKU-Size Size Price Qty
B2094-5 5 mg
$135.00
B2094-25 25 mg
$535.00
More Sizes Get Quote

Product Details

Alternate Name 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride
Appearance Yellow solid
CAS # 212391-63-4
Molecular Formula C₂₆H₂₇Cl₂N₅O₂.2HCl
Molecular Weight 612.37
Purity ≥98% by HPLC
Solubility DMSO (>40 mg/ml)
SMILES CCN(CC)CCOC1=CC=C(C=C1)NC2=NC=C3C=C(C(=O)N(C3=N2)C)C4=C(C=CC=C4Cl)Cl.Cl.Cl
InChi InChI=1S/C26H27Cl2N5O2.2ClH/c1-4-33(5-2)13-14-35-19-11-9-18(10-12-19)30-26-29-16-17-15-20(25(34)32(3)24(17)31-26)23-21(27)7-6-8-22(23)28;;/h6-12,15-16H,4-5,13-14H2,1-3H3,(H,29,30,31);2*1H
InChi Key NADLBPWBFGTESN-UHFFFAOYSA-N
PubChem CID 9916391
MDL Number MFCD18086890
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PD-166285 is a potent, ATP-competitive and broadly active protein tyrosine kinase inhibitor. It inhibits tyrosine kinases c-Src, fibroblast growth factor receptor 1 (FGFR1), and platelet-derived growth factor receptor β(PDGFRβ) (IC₅₀ values are 8.4, 39.3 and 98.3 nM respectively). PD-166285 also displays inhibitory activity against mitogen-activated protein kinase (IC₅₀ = 5 μM) and protein kinase C (IC₅₀ = 22.7 μM).


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