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PD-1/PD-L1 Inhibitor 1

PD1-PD-L1 inhibitor 1 (PD1-PD-L1-IN-1) is an inhibitor of the protein-protein interaction
Catalog #: B1213

In stock

SKU-Size Size Price Qty
B1213-25 25 mg
$475.00
B1213-5 5 mg
$125.00
More Sizes Get Quote

Product Details

Alternate Name (2S)-1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-2-piperidinecarboxylic acid
Appearance White to off-white solid
CAS # 1675201-83-8
Molecular Formula C₂₉H₃₃NO₅
Molecular Weight 475.58
Purity ≥98% by HPLC
Solubility DMSO(>30 mg/ml)
SMILES CC1=C(C=CC=C1COC2=CC(=C(C(=C2)OC)CN3CCCCC3C(=O)O)OC)C4=CC=CC=C4
InChi InChI=1S/C29H33NO5/c1-20-22(12-9-13-24(20)21-10-5-4-6-11-21)19-35-23-16-27(33-2)25(28(17-23)34-3)18-30-15-8-7-14-26(30)29(31)32/h4-6,9-13,16-17,26H,7-8,14-15,18-19H2,1-3H3,(H,31,32)/t26-/m0/s1
InChi Key ZBOYJODMIAUJHH-SANMLTNESA-N
PubChem CID 91663303
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PD1-PD-L1 inhibitor 1 (PD1-PD-L1-IN-1) is an inhibitor of the PD1-PD-L1 protein-protein interaction. Also acts as an immunomodulator. Programmed death ligand 1 (PD-L1) is a protein in humans that is encoded by the CD274 gene and the upregulation of PD-L1 allows cancers to evade the host immune system. High tumor expression of PD-L1 was associated with increased tumor aggressiveness and a 4.5-fold increased risk of death.


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