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PD-0332991 isethionate

A highly specific inhibitor of Cdk4 and Cdk6
Catalog #: 9480
SKU-Size Size Price Qty
9480-5 5 mg
9480-25 25 mg
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Product Details

Alternate Name 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one isethionate salt; Palbociclib
Appearance Yellow solid
CAS # 827022-33-3
Molecular Formula C₂₄H₂₉N₇O₂.C₂H₆O₄S
Molecular Weight 573.66
Purity ≥98% by HPLC
Solubility Water (~55 mg/ml) or DMSO (~ 6 mg/ml)
InChi InChI=1S/C24H29N7O2.C2H6O4S/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32;3-1-2-7(4,5)6/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29);3H,1-2H2,(H,4,5,6)
PubChem CID 11478676
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


PD0332991 is a highly specific inhibitor of Cdk4 (IC₅₀ = 11 nM) and Cdk6 (IC₅₀ = 16 nM). Displays selectivity for Cdk4/6 over a panel of 34 additional protein kinases (IC₅₀ values are > 10 μM).

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