A MEK inhibitor
Catalog #: 1643 | abID:

Product Details

Alternate Name N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2[(2-fluoro-4-iodophenyl)amino]-benzamide
Appearance Off-white solid
CAS # 391210-10-9
Molecular Formula C₁₆H₁₄F₃IN₂O₄
Molecular Weight 482.2
Purity ≥95% by HPLC
Solubility DMSO (20 mg/ml) of EtOH (20 mg/ml)
InChi InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1
PubChem CID 9826528
MDL Number MFCD08435926
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A selective and ATP non-competitive MEK inhibitor that suppresses the phosphorylation of ERK in murine colon 26 tumors (IC₅₀ = 0.33 nM). In combination with the GSK-3 inhibitor CHIR99021, prevents cell differentiation and sustains self-renewal of embryonic stem (ES) cells.

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Abujarour et al., Myogenic Differentiation of Muscular Dystrophy-Specific Induced Pluripotent Stem Cells for Use in Drug Discovery. Stem Cells Trans Med, Feb 2014; 3: 149 - 160.
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