Product Details
| Alternate Name | N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2[(2-fluoro-4-iodophenyl)amino]-benzamide |
|---|---|
| Appearance | Off-white solid |
| CAS # | 391210-10-9 |
| Molecular Formula | C₁₆H₁₄F₃IN₂O₄ |
| Molecular Weight | 482.2 |
| Purity | ≥95% by HPLC |
| Solubility | DMSO (20 mg/ml) of EtOH (20 mg/ml) |
| SMILES | C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOCC(CO)O |
| InChi | InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1 |
| InChi Key | SUDAHWBOROXANE-SECBINFHSA-N |
| PubChem CID | 9826528 |
| MDL Number | MFCD08435926 |
| Handling | Protect from air and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A selective and ATP non-competitive MEK inhibitor that suppresses the phosphorylation of ERK in murine colon 26 tumors (IC₅₀ = 0.33 nM). In combination with the GSK-3 inhibitor CHIR99021, prevents cell differentiation and sustains self-renewal of embryonic stem (ES) cells.
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Abujarour et al., Myogenic Differentiation of Muscular Dystrophy-Specific Induced Pluripotent Stem Cells for Use in Drug Discovery. Stem Cells Trans Med, Feb 2014; 3: 149 - 160.
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