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PCNA, Human Recombinant

A processivity factor for DNA polymerase δ
Catalog #: P1562
SKU-Size Size Price Qty
P1562-20 20 μg
$165.00
P1562-100 100 μg
$525.00
More Sizes Get Quote

Product Details

Alternate Name Proliferating cell nuclear antigen, MGC8367, Proliferating cell nuclear antigen, Proliferating cell nuclear antigen, PCNA
Gene Symbol PCNA
Gene ID 5111
Accession # P12004
Source E. coli
Appearance Liquid
Physical Form Description Liquid
Molecular Weight 28 kDa
Purity by SDS-PAGE >95%
Amino Acid Sequence aa 1-261
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PCNA (Proliferating Cell Nuclear Antigen) is found in the nucleus and is a cofactor of DNA polymerase delta. This protein is associated with DNA synthesis and repair. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. It appears during late G1- phase, Sphase of mitosis and persists until the end of the M-phase because of its long biological half-life. PCNA may be induced by UV irradiation, growth factors and eventually by neighbouring tumours. Recombinant human PCNA, was expressed in E. coli and purified by conventional chromatography techniques.


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