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Parthenolide

A NF-κB activation inhibitor
Catalog #: 1868
SKU-Size Size Price Qty
1868-10 10 mg
$70.00
1868-50 50 mg
$275.00
More Sizes Get Quote

Product Details

Alternate Name (1aR-[1aR*,4E,7aS*,-10aS*,-10bR*])-2,3-6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclo deca[1,2-b]furan-9(1aH)-one
Appearance White to off-white solid
CAS # 20554-84-1
Molecular Formula C₁₅H₂₀O₃
Molecular Weight 248.32
Purity ≥97% by TLC
Solubility DMSO (100 mg/ml) or EtOH (20 mg/ml)
SMILES CC1=CCCC2(C(O2)C3C(CC1)C(=C)C(=O)O3)C
InChi InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5+/t11-,12-,13+,15+/m0/s1
InChi Key KTEXNACQROZXEV-PVLRGYAZSA-N
PubChem CID 7251185
MDL Number MFCD00134592
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

An anti-inflammatory agent. Specifically inhibits activation of NF-κB by preventing the degradation of IκBα and IκBβ. Inhibits activation of MAP kinase (MAPK/ERK) and generation of leukotriene B4 and thromboxane B2. Potent anticancer agent. Induces apoptosis in various cancer cell lines. Specifically inhibits histone deacetylase 1 (HDAC1) without affecting other class I/II HDACs.


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