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PARP Antibody (Clone 839120)

Monoclonal Antibody to detect PARP in human samples.
Catalog #: 6659

Product Details

Cat # +Size 6659-100
Size 100 μl
Antibody Target PARP
Alternate Name PARP1, ADPRT, PPOL, NAD (+) ADP-ribosyltransferase 1
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG1
Immunogen E. coli-derived recombinant human PARP- Thr 373-Glu 540
Accession # P09874
Gene ID 142
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 100 µl of 0.5 mg/ml antibody in sterile PBS.
Purification Protein A/G Purified Antibody
Species Reactivity Human
Application Western Blot, IHC
Positive Control Western Blot: HeLa cell lysate, IHC: human breast tissue.
Application & Usage WB: 1 µg/ml, IHC: 8-25 µg/ml.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress. This protein can be cleaved by many ICE-like Caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa). PARP helps cells to maintain their viability; cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis.

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